Clomiphene is available with a prescription generically and under the brand names Clomid and Serophene.

It is the most widely prescribed of all fertility drugs.

Clomid is an ovulatory stimulant. It is used for the treatment of ovulation dysfunction in women desiring pregnancy. Clomid stimulates the release of pituitary hormones necessary for ovulation to occur. It is important to exclude other hormonal causes of ovulation dysfunction and other causes of infertility before undergoing Clomid treatment.

In women with unexplained infertility, Clomid is also used empirically to stimulate multiple follicle (egg) formation. In this situation, it is often used in conjunction with intrauterine insemination (IUI).

It is important to exclude pregnancy, ovarian enlargement and ovarian cyst before each Clomid treatment cycle.

Clomid is orally administered, available in 50 mg tablets.

It is usually taken in 5 day cycles. Treatment begins with a low dose, 50 mg tablet daily for 5 days. The dose is increased only in those patients who do not ovulate in response to the 50 mg dose.

Ovulation usually occurs 5 to 10 days after treatment.

Intercourse or IUI is timed to coincide with the expected time of ovulation. Timing of ovulation can be determined with basal body temperature charting, over the counter ovulation kits and pelvic ultrasounds.

Approximately 70 – 80% of patients with ovulation dysfunction will ovulate, and about 60 – 70% will get pregnant within six cycles of use

Side Effects of Clomid:

  1. Ovarian enlargement and cyst formation presenting as bloating, abdominal pain, tenderness and pressure
  2. Flushing
  3. Nausea, vomiting or diarrhea
  4. Breast tenderness
  5. Blurred vision or other visual disturbances
  6. Headache
  7. Multiple pregancy – up to 8%, mostly twins.