PGT-M (Preimplantation Genetic Testing for Monogenic Disorders / Single Gene Defects)
Another common type of genetic testing for embryos is used to identify specific genes that are in a family tree and are known to cause disease. There are hundreds of examples of disease states that result from defects of a single gene (eg., sickle cell anemia, muscular dystrophy, cystic fibrosis). PGT-M requires that DNA probes, specific to the family gene, be prepared and tested prior to being used to identify the gene in embryos. The process to prepare and test a DNA probe may take weeks or months to complete, but will result in an ability to remove affected embryos and transfer only embryos with the normal gene. In this way, a disease may be eliminated in a family line.