Letrozole is available with a prescription generically and under the brand name Femara. It is a medication that has been approved for use by the FDA for the treatment of certain types of breast cancer. It is also commonly used as “off label” for the treatment of ovulation disorders in infertility. Intercourse or intrauterine insemination (IUI) is timed to coincide with the expected time of ovulation. Timing of ovulation can be determined with basal body temperature charting, over the counter ovulation kits, and pelvic ultrasounds.