Genetic Cause for Premature Ovarian Failure

At Viera Fertility Center, we often see patients experiencing premature ovarian failure. While women expect to enter menopause marking the end of fertility during middle age, young women experiencing unexpected early ovarian failure can find that the condition thwarts efforts toward starting a family.

A new study has linked premature ovarian failure with a woman’s genetic history. The results, published in The New England Journal of Medicine and Human and Molecular Genetics journals, demonstrate for the first time that mutation in STAG3 gene is a major cause of human fertility disorders as it provokes a loss of function of the protein it encodes.

STAG3 functions to encode cells with proteins necessary to sustain and develop life. Without this functionality, infertility can result. If you’re experiencing premature ovarian failure, contact your Melbourne fertility center today for help overcoming genetics in order to achieve the family of your dreams!


Spanish National Research Council (CSIC). (2014, March 5). Genetic cause found for premature ovarian failure. ScienceDaily. Retrieved March 25, 2014 from